61 yo female presented with large peripheral foci of necrotizing retinitis in the supratemporal quadrant in her left eye with positive serum toxoplasmosis titers which corresponded with a positive PCR for Toxoplasmosis on vitreous tap.  She was subsequently treated with a 6 week course of azithromycin.  She additionally was treated with Valacyclovir and Ganciclovir.  The vitreous failed to clear with this course, and she developed a posterior subcapsular cataract.  She then underwent a combined Phacoemulsification/IOL implant/Vitrectomy.  Postoperatively her vision has cleared to 20/40, with a "quiet" appearing eye.  Wide-angle fluorescein angiography reveals diffuse vasculitis with disc leakage and no cystoid macular edema.  Vitreous biopsy is negative for monoclonal proliferation (lymphoma), however continues to have a positive PCR for toxoplasmosis.  Lyme, RPR are negative.  PPD and CXR are negative and Tuberculosis PCR of vitreous sample is negative.  However in follow-up a new lesion was noted.